Mike and Josie Harper Cancer Research Institute

Innovative Drug Discovery and DesignConnecting Research Strengths Across the State Collaborative Teams Drive Innovation Developing Imaging Tools for Cancer Detection and TreatmentEstablishing Preclinical Models for Drug TestingDeciphering Distinct Molecular Signatures of Cancer



Investigators in the Harper Cancer Research Institute (HCRI) are dedicated to conducting innovative and integrative research that confronts the complex challenges of cancer.  Our programmatic structure fosters multi-disciplinary cancer research by promoting interactions among research groups with distinct expertise and by training young scientists to work across scientific fields. Clinical partnerships provide key translational insight and strengthen the mission of discovery.


HCRI Mission Statement:

Innovative and integrative research confronting the complex challenges of cancer


Identifying Effective Treatments for Colon Cancer

August 19, 2016 • Categories: Announcements and Homepage

In recent years researchers have begun to understand that the development of colon cancer, which is the second most common cancer in the United States, can impact the genome and cause protein changes within cancer cells. This knowledge has brought new medications and targeted therapies to the marketplace and now Notre Dame researcher Amanda Hummon is evaluating the effectiveness of these treatments.

Uncovering a new pathway to halting metastasis

August 18, 2016 • Categories: Announcements and Homepage

Zachary Schafer

Metastasis, the process by which cancer cells leave the primary tumor and spread to other sites in the body, is responsible for more than 90 percent of cancer deaths. Thus, there is a significant need to improve the therapeutic options for patients who suffer from metastatic disease. New research from the laboratory of Zachary T. Schafer, associate professor in the Department of Biological Sciences, Coleman Foundation Collegiate Chair of Cancer Biology and researcher in the Harper Cancer Research Institute, could lead to these new therapies.

Katherine Ward finds niche in the convergence of science and business

August 18, 2016 • Categories: Announcements and Homepage

Katie Ward

While pursuing that Ph.D, Ward heard about the ESTEEM program, a master’s degree in entrepreneurship in which students take ideas from the concept stage through the process of launching a startup company. In Ward’s case, this was the convergence of two paths – science and business — that she hadn’t been familiar with.


The 1st Joint Meeting of ISFP and PA Workshop

Tue Oct 17, 2017 • Shizuoka, Japan • Calendars: HCRI Events Calendar and Homepage

XXIIIrd International Congress on Fibrinolysis & Proteolysis

XVIth International Workshop on Molecular and Cellular Biology of Plasminogen Activation

October 17-21, 2016

Sponsored by Hamamatsu University School of Medicine

International Advisory Board Includes:

Dr. Francis Castellino and Dr. Victoria Ploplis…