Mike and Josie Harper Cancer Research Institute

Innovative Drug Discovery and DesignConnecting Research Strengths Across the State Collaborative Teams Drive Innovation Developing Imaging Tools for Cancer Detection and TreatmentEstablishing Preclinical Models for Drug TestingDeciphering Distinct Molecular Signatures of Cancer



 

About

Investigators in the Harper Cancer Research Institute (HCRI) are dedicated to conducting innovative and integrative research that confronts the complex challenges of cancer.  Our programmatic structure fosters multi-disciplinary cancer research by promoting interactions among research groups with distinct expertise and by training young scientists to work across scientific fields. Clinical partnerships provide key translational insight and strengthen the mission of discovery.

 

HCRI Mission Statement:

Innovative and integrative research confronting the complex challenges of cancer

News

Notre Dame students receive NSF Graduate Research Fellowships

April 23, 2014 • Categories: Announcements and Homepage

Main Building

The National Science Foundation (NSF) recently announced the recipients of this year’s Graduate Research Program Fellowships (GRPF). Seven College of Science students and one alumnus received awards. In addition, five science students received honorable mentions.

The fellowship provides three years of support for the graduate education of students who have demonstrated the potential for significant achievements in science and engineering research.  Past NSF Fellows include individuals who have made significant breakthroughs in science and engineering research, as well as some who have been honored as Nobel laureates.

Eleven ND graduate students win NSF-GRFP awards

April 23, 2014 • Categories: Announcements and Homepage

The National Science Foundation (NSF) recently announced the winners of the 2014 Graduate Research Fellowship Program (GRFP), with eleven current Notre Dame students winning the prestigious award and another five earning honorable mention. This year’s number is up from last year’s nine awardees, which was previously the highest number ever received by Notre Dame students.…

Bridging the Gaps Between the Clinic and the Laboratory

April 23, 2014 • Categories: Announcements and Homepage

 Around 90% of cancer deaths can be attributed due to metastasis, the spreading of primary tumor cells to distant organs. Dr. Siyuan Zhang’s lab works to further our understanding of the early stages of metastasis and in turn, how to treat it more effectively. Under the guidance of Dr. Zhang, undergraduates like Dennis Lee are using genetic editing tools to create lineage reporter cell lines and investigate the evolution of metastasis through intravital two photon imaging.

            Sophomore Dennis Lee is a biology and psychology major at Notre Dame. Lee is a part of the Building Bridges program and was assigned Dr. Zhang from the Harper Cancer Research Institute as a mentor. Building Bridges is a mentoring program that matches underrepresented freshmen with faculty from the departments that students wish to explore as possible majors. With no previous lab research experience, Lee shadowed the Zhang lab during the spring semester of his freshmen year and officially joined this past fall.

            “To put it simply, we are generating dual-reporter cancer cell line through genetic editing that can be distinguished as ‘loose’ invasive metastatic state, or ‘sticky’ tumor state. Afterward the injection, through cranial window in vivo imaging, we’ll be able to directly observe evolution of metastasis in their microenvironment,” Lee said.

As researchers gain more knowledge on the mechanisms behind metastatic evolution, more new therapies and clinical trials can be done.

Events

Strike Out Cancer - Game 1 of Double-Header

Sun Apr 27, 2014 1:00PM - 2:50PM • Melissa Cook Stadium, Notre Dame • Calendars: Homepage and HCRI Events Calendar

Notre Dame's Women's Softball vs. Maryland

 

Notre Dame softball's signature awareness initiative, Strikeout Cancer, began supporting leukemia awareness in 2011 in solidarity for Irish head coach Deanna Gumpf and her daughter, Tatum, who was diagnosed with acute lymphoblastic leukemia in the summer of 2010. Now an annual celebration, the proceeds directly benefit South Bend's Memorial Children's Hospital (where Tatum started her treatments) and children throughout Indiana who have been diagnosed with cancer.…

Strike Out Cancer - 2nd game of Double-Header

Sun Apr 27, 2014 3:00PM - 5:50PM • Melissa Cook Stadium, Notre Dame • Calendars: Homepage and HCRI Events Calendar

Notre Dame softball's signature awareness initiative, Strikeout Cancer, began supporting leukemia awareness in 2011 in solidarity for Irish head coach Deanna Gumpf and her daughter, Tatum, who was diagnosed with acute lymphoblastic leukemia in the summer of 2010. Now an annual celebration, the proceeds directly benefit South Bend's Memorial Children's Hospital (where Tatum started her treatments) and children throughout Indiana who have been diagnosed with cancer.…

4th Annual Strike Out Cancer game

Mon Apr 28, 2014 7:00PM - 8:50PM • Melissa Cook Stadium, Notre Dame • Calendars: Homepage and HCRI Events Calendar

Notre Dame Womens Softball vs. Maryland

Notre Dame softball's signature awareness initiative, Strikeout Cancer, began supporting leukemia awareness in 2011 in solidarity for Irish head coach Deanna Gumpf and her daughter, Tatum, who was diagnosed with acute lymphoblastic leukemia in the summer of 2010. Now an annual celebration, the proceeds directly benefit South Bend's Memorial Children's Hospital (where Tatum started her treatments) and children throughout Indiana who have been diagnosed with cancer.…