Mike and Josie Harper Cancer Research Institute

Innovative Drug Discovery and DesignConnecting Research Strengths Across the State Collaborative Teams Drive Innovation Developing Imaging Tools for Cancer Detection and TreatmentEstablishing Preclinical Models for Drug TestingDeciphering Distinct Molecular Signatures of Cancer



Investigators in the Harper Cancer Research Institute (HCRI) are dedicated to conducting innovative and integrative research that confronts the complex challenges of cancer.  Our programmatic structure fosters multi-disciplinary cancer research by promoting interactions among research groups with distinct expertise and by training young scientists to work across scientific fields. Clinical partnerships provide key translational insight and strengthen the mission of discovery.


HCRI Mission Statement:

Innovative and integrative research confronting the complex challenges of cancer


Notre Dame’s junior faculty achieve record success in nationally competitive awards

October 27, 2014 • Categories: Announcements and Homepage

National Science Foundation

The National Science Foundation (NSF) has recognized eight University of Notre Dame faculty from the Colleges of Arts and Letters, Engineering and Science for their excellence in research with an Early Career Development (CAREER) Award. Additionally, two faculty members have been awarded Young Investigator Program (YIP) Awards from the Army Research Office.

IUSM-SB Honors Outstanding Physicians at the annual Medicine Ball

October 27, 2014 • Categories: Announcements and Homepage

Blakesley, Halperin named 'Outstanding Physicians'

Michael Blakesley, M.D., and David Halperin, M.D., longtime instructors of Gross Anatomy at Indiana University School of Medicine-South Bend (IUSM-SB), will be honored as Outstanding Physicians of the Year at the 2014 Medicine Ball on Saturday, Nov. 8. …

Zhang Awarded The Breast Cancer Research Program Breakthrough Grant

October 23, 2014 • Categories: Announcements and Homepage

We are proud to congratulate Dr. Siyuan Zhang, Professor of Cancer Research at the University of Notre Dame and Harper Cancer Research Institute, for being awarded the Breast Cancer Research Program (BCRP) Breakthrough Award. 


John A. Lynch Lecture: "Wnt Signaling and Stem Cell Control"

Fri Oct 31, 2014 12:30PM - 1:30PM • 101 Jordan Hall of Science • Calendars: Homepage


Roel Nusse
Professor of Developmental Biology,  Virginia and Daniel K. Ludwig Professor of Cancer Research
Investigator, Howard Hughes Medical Institute,  Stanford University

A major focus of the Nusse lab is Wnt signaling, which is essential for regulating stem cells. How this is achieved is far from clear and is the subject of studies in the lab, both in vivo and in cell culture. The types of questions that the Nusse lab investigates are: What role do Wnt-responsive cells play in tissue maintenance and regeneration? How is the expression of Wnt signals regulated, in normal and injured tissues? 
Does oriented Wnt signaling polarize asymmetrically dividing stem cells, which plays a central role in tissue homeostasis and regeneration.

Precision Medicine and the Future of Healthcare: Bioanalytical and Bioengineering Solutions

Mon Nov 10, 2014 8:30AM - 4:00PM • Eck Visitor's Center Auditorium • Calendars: Homepage


3rd Annual AD&T Symposium
November 10, 2014, at the University of Notre Dame
Registration begins at 8:30 a.m. at the Eck Visitor’s Center Auditorium. Program begins at 9:00 a.m.
Pre-register to: mendres1@nd.edu
Participation is free. Lunch and an afternoon reception will be provided.

ACMS Colloquim: "An embedded multiscale approach for studying of blood perfusion and drug transport in tumors"

Mon Dec 8, 2014 4:15PM - 5:15PM • 127 Hayes-Healy Center • Calendars: Homepage


Paolo Zunino, Department of Engineering and Materials Science, University of Pitsburgh, will give a colloquium titled, "An embedded multiscale approach studying of blood perfusion and drug transport in tumors" at 4:15 PM in 127 Hayes-Healy Center.