Mike and Josie Harper Cancer Research Institute

Innovative Drug Discovery and DesignConnecting Research Strengths Across the State Collaborative Teams Drive Innovation Developing Imaging Tools for Cancer Detection and TreatmentEstablishing Preclinical Models for Drug TestingDeciphering Distinct Molecular Signatures of Cancer



Investigators in the Harper Cancer Research Institute (HCRI) are dedicated to conducting innovative and integrative research that confronts the complex challenges of cancer.  Our programmatic structure fosters multi-disciplinary cancer research by promoting interactions among research groups with distinct expertise and by training young scientists to work across scientific fields. Clinical partnerships provide key translational insight and strengthen the mission of discovery.


HCRI Mission Statement:

Innovative and integrative research confronting the complex challenges of cancer


New study identifies potential targets for personalized cancer vaccines

October 22, 2014 • Categories: Announcements and Homepage

Notre Dame researchers and their collaborators explain how identifying distinctions between mutant (yellow) and normal (orange) immune targets can help locate neo-epitopes that elicit anti-cancer immune responses

A team of University of Notre Dame scientists, in collaboration with researchers at the University of Connecticut, have announced the results of a new study on identifying potential targets for personalized cancer vaccines. The paper, “Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity,” was recently published in the Journal of Experimental Medicine. The research group at Notre Dame was led by Brian Baker, associate dean for research and graduate studies and professor of chemistry and biochemistry, and included Steven Corcelli, associate professor of chemistry and biochemistry, and graduate student Cory Ayers.

Littlepage - Indiana CTSI poster presentation winner

October 20, 2014 • Categories: Announcements and Homepage

Six researchers were honored at a poster presentation during the Sixth Annual Indiana Clinical and Translational Sciences Institute Meeting, "From Academic Centers to Population Health," on Sept. 26.

Winners were honored for the top three posters in the both the Indiana CTSI-supported researcher category and the scholars and trainees category. Each winner received $1,000.

Taylor named vice-chair for Gordan Research Conference on Natural Products

October 20, 2014 • Categories: Announcements and Homepage

Rich Taylor

Rich Taylor, associate vice president for research and professor of chemistry and biochemistry, presented a paper on his research, "Chemical and Biological Synthesis of Polyketide Natural Products", at the 2014 Gordon Research Conference on Natural Products at its annual July meeting. During this year’s conference, Taylor was elected Vice-Chair of the 2015 and Chair of the 2016 conferences to be held at Proctor Academy in Andover, N.H. This annual international meeting provides a forum for experts to share unpublished research results and engage in scientific discussions.


RiverBend Cancer Services’ “Breakthrough” event

Wed Oct 22, 2014 5:30PM - 8:00PM • Debartolo Performing Arts Center at Notre Dame • Calendars: Homepage

This year's Breakthrough event, Game Plan for Survival, features keynote speaker Meg Brown, former Texas Longhorn basketball player, and her inspirational story of surviving a nearly fatal battle with non-Hodgkin's lymphoma. Meg will tell her six survival secrets, plus a short presentation will be given by Dr. Sharon Stack, Director of Harper Cancer Research Institute, on local cancer research efforts.The event will begin on the second floor lobby at DeBartolo Performing Arts Center at the University of Notre Dame and the Keynote Address will be held in the Browning Cinema. There will be refreshments and FREE ADMISSION

Making Strides Against Cancer

Sat Oct 25, 2014 9:00AM - 12:00PM • Howard Park, South Bend, IN • Calendars: Homepage

Come join the Harper Cancer Research Institute's TeMaking Strides Against Breast Canceram of walkers for the Making Strides Against Cancer event.  The 3-mile walk winds through down town South Bend and back along the St. Joseph River.


Fundraising is encouraged, but not required.  On-site registration begins at 8:00am.  Walk begins at 9:00am.…

ACMS Colloquium: "Statistical methods for cancer genomics"

Mon Oct 27, 2014 4:15PM - 5:15PM • 127 Hayes-Healy Center • Calendars: Homepage

Wei Sun

Wei Sun
Department of Biostatistics and Genetics
Carolina Center for Genome Sciences
UNC School of Medicine