Research Scientist at the University of Notre Dame
University of Notre Dame
Magnetoelectric nanoparticles offer targeted and timed release in cancer cells
As a research scientist at Notre Dame's Center for Nano Science and Technology, Dr. Stewart is developing magnetoelectric drug delivery platforms and experimental methods to test targeted delivery and on-demand release of drugs to specific cancer cell types. By taking advantage of the electric properties of cells, magnetoelectric nanoparticles (MENs) can specifically penetrate cancer cells while sparing normal cells without requiring the use of targeting agents.
Dr. Stewart's lab is developing new ways to decorate MENs with anti-cancer drugs to treat a variety of cancer types. MENs decorated with anti-cancer drugs can penetrate cells with the application of a d.c. magnetic field, then drugs are released intracellularly by applying an a.c. magnetic field effectively "shaking off" the drug inside of cells. Since MENs can cross the blood brain barrier, Dr. Stewart seeks to enhance collaborations with groups studying neurological cancers. Currently her work focuses on ovarian, glioblastoma, and melanoma.