Assistant Professor of Electrical Engineering at the University of Notre Dame
University of Notre Dame
Prof. O’Sullivan is engaged in translational research involving the development and application of noninvasive optical imaging technologies. Uniting the principles of optical spectroscopy, semiconductor physics, microfabrication, and signal processing with human physiology and metabolism, the mission of his lab is to create the next generation of noninvasive medical imaging sensors and instrumentation. In particular, Prof. O’Sullivan is advancing diffuse optical spectroscopy and imaging, which allows for quantitative measurements of tissue architecture and metabolic function. This work, while applicable to many diseases, is focused on applications in breast oncology including risk assessment, screening, differential diagnosis, and predicting individual response to chemotherapy. DOS-based imaging is complementary to other breast imaging modalities because it does not involve ionizing radiation, provides excellent contrast in young women (as opposed to mammography) and is much more accessible (lower cost) than MRI.
T. D. O'Sullivan, A. Leproux, J.-H. Chen, S. Bahri, A. Matlock, D. Roblyer, C. E. McLaren, W.-P. Chen, A. E. Cerussi, M.-Y. Su, B. J. Tromberg. Optical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy. Breast Cancer Res. 2013; 15:R14.
T. D. O'Sullivan, R. T. Heitz, N. Parashurama, D. B. Barkin, B. A. Wooley, S. S. Gambhir, J. S. Harris, and O. Levi. Real-time, continuous, fluorescence sensing in a freely-moving subject with an implanted hybrid VCSEL/CMOS biosensor. Biomed Opt Express. 2013; 4:1332-41.
T. D. O'Sullivan, A. E. Cerussi, D. J. Cerussi, B. J. Tromberg. Diffuse optical imaging using spatially and temporally modulated light. J Biomed Opt. 2012; 17(7):071311.
S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santro, S. Xu, T. D. O'Sullivan, D. Hsiang, R. Mehta, J. Butler, B. J. Tromberg. Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy. Cancer Res. 2012; 72:4318-4328.