Assistant Professor, Electrical Engineering
University of Notre Dame
Prof. O’Sullivan is engaged in translational research involving the development and application of noninvasive optical imaging technologies. Uniting the principles of optical spectroscopy, semiconductor physics, microfabrication, and signal processing with human physiology and metabolism, the mission of his lab is to create the next generation of noninvasive medical imaging sensors and instrumentation. In particular, Prof. O’Sullivan is advancing diffuse optical spectroscopy and imaging, which allows for quantitative measurements of tissue architecture and metabolic function. This work, while applicable to many diseases, is focused on applications in breast oncology including risk assessment, screening, differential diagnosis, and predicting individual response to chemotherapy. DOS-based imaging is complementary to other breast imaging modalities because it does not involve ionizing radiation, provides excellent contrast in young women (as opposed to mammography) and is much more accessible (lower cost) than MRI.
N. Bosschaart, A. Leproux, O. Abdalsalam, W. Chen, C. E. McLaren, B. J. Tromberg, T. D. O’Sullivan. Diffuse optical spectroscopic imaging for the investigation of human lactation physiology: a case study on mammary involution. J Biomed Opt. 2019; 24(5):056006.
V. Kitsmiller and T. D. O’Sullivan. Next generation frequency domain diffuse optical imaging systems using silicon photomultipliers. Opt. Letters 2019; 44(4): 562-565.
V. J. Kitsmiller, M.M. Dummer, K. Johnson, G. D. Cole, T. D. O’Sullivan. Frequency domain diffuse optical spectroscopy with a near-infrared tunable vertical cavity surface emitting laser. Opt. Express 2018; 26(16):21033-21043.
H.S. Yazdi, T. D. O’Sullivan, A. Leproux, B. Hill, et al. Mapping breast cancer blood flow index, composition, and relative metabolism in a human subject using broadband, multimodal diffuse optical spectroscopies. J Biomed Opt. 2017; 22(4):045003.
B. J. Tromberg, Z. Zhang, A. Leproux, T. D. O’Sullivan, et al. Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging. Cancer Res. 2016; 76(20):5933-44.