Assistant Professor, Aerospace and Mechanical Engineering at the University of Notre Dame
University of Notre Dame
Dr. Yoon’s lab utilizes ultrasonic transducers and microfluidic chips to develop integrated device to engineer cells for patient-specific therapy. One of the main thrusts is the generation of induced pluripotent stem cells (iPSCs) with no mutagenesis. A new device for the intracellular delivery of macromolecules has been developed for this purpose. Ultrasonic transducer will be developed to improve the specificity, efficiency, and throughput of intracellular delivery. The generated iPSC will be used for the treatment of neurodegenerative diseases. On the other hand, the integrated device will improve the recovery and efficiency of the isolation of viable circulating tumor cells (CTC) for the study of fundamental biophysics of metastasis and monitoring therapeutic responses. In addition to the development of integrated devices, we are also interested in combining the consequences of mechanotransduction and the outbreak of a certain disease such as cancer. Developing a novel way to stimulating specific cells using high frequency ultrasound may unveil new mechanisms of outbreak, relapse, and resistance to therapy of cancer. Molecular imaging using genetically encoded biosensors will be used for the study of mechanotransduction ion channels.