Director of Notre Dame - California, Program Director for Rare Disease Research and Development in the Warren Center for Drug Discovery, and Professor of Chemistry and Biochemistry at the University of Notre Dame
University of Notre Dame
Richard Taylor’s laboratory exploits the complementary powers of chemical and biological synthetic tools to generate natural products and natural product analogues. There efforts are motivated by the desire to identify compounds with novel biological activities in cancer and rare diseases. The laboratory uses a combination of synthetic, computational, and molecular biological studies. Researchers are particularly interested in the correlation between unique natural product structures and their corresponding biological activities.
The research is significant because, despite the advent of combinatorial chemistry and high-throughput screening during the past decade, the number of new biological targets that have emerged from the pharmaceutical industry is remarkably small. Natural products are especially important because evolution has created these compounds to transport and modulate biological function. The detailed study of natural products with unknown or unique modes of action represents a paradigm with the ability to identify new biological targets.