Karen Cowden Dahl
Associate Professor of Biochemistry & Molecular Biology at Indiana University School of Medicine - South Bend
Gene Regulation in Ovarian Cancer
Ovarian cancer is one of the leading causes of cancer death in women in the US. One of the major challenges in treating ovarian cancer is acquired resistance to the chemotherapeutic drugs. The lab of Karen Cowden Dahl, assistant professor of biochemistry and molecular biology, investigates processes by which ovarian cancer cells acquire drug resistance. The lab is investigating how genes involved in ovarian cancer progression are regulated and how they interact in order to contribute to the disease process. We hope that drugs that impede these processes can be developed and when given to patients will increase their response to cancerkilling agents. These studies are supported by the Howard Temin Pathway to Independence Award from the National Cancer Institute and an award from the Eck Institute for Global Health at the University of Notre Dame.