Hsueh-Chia Chang

Hsueh-Chia Chang

Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics at the University of Notre Dame

University of Notre Dame


Micro/Nanofluidics and molecular sensing for cancer diagnostics

Professor Hsueh-Chia Chang's group works on micro/nanofluidics and molecular sensing.  The technologies they currently work on include a nanoporous membrane/granule sensor for nucleic acids based on ion flux, circulating tumor cell and vesicle separation devices, biomolecule concentration and stacking by electrokinetic depletion/isotachophoresis, nanopore cell lysing and transfection, high-resolution microRNA profiling array based on tip plasmonics, single cell isolation by surface acoustic waves,  free-flow isoelectric separation of proteins by on-chip pH actuation and patterning, photoconductive/nanowire transistor sensors. The emphasis is on low-cost and portable devices that can be used by lay people, without significant loss in sensitivity and selectivity.  

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