Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics at the University of Notre Dame
University of Notre Dame
MICRO/NANOFLUIDICS FOR LIQUID BIOPSY AND THERAPY DISCOVERY
Professor Hsueh-Chia Chang's group works on micro/nanofluidics and molecular sensing technologies for cancer screening and therapy development. The technologies they currently work on include nanoporous membrane molecular sensors, chip electrophoresis, isotachophoresis and dielectrophoresis for fractionation and stacking of molecules and exosomes, solid-state nanopores for precise quantification of microRNA biomarkers, a nanocone TIRF array for real-time multi-plexed microRNA/protein profiling, surface acoustic wave modules for reagent-free cell/exosome lysing, non-optical real-time and isothermal replacement hybridization PCR, high-throughput electrokinetic droplet microfluidics for digital PCR and cell encapsulation, photoconductive/nanowire transistor sensors for quantifying proteins, micro-filters for circulating tumor cells and manufacturing strategies to integrate these technologies into functioning biochips. The emphasis is on low-cost and portable devices that can be used by lay people, without significant loss in sensitivity and selectivity. Current applications are for pancreatic, lung and breast cancer screening.