Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics at the University of Notre Dame
University of Notre Dame
Micro/Nanofluidics and molecular sensing for cancer diagnostics
Professor Hsueh-Chia Chang's group works on micro/nanofluidics and molecular sensing. The technologies they currently work on include a nanoporous membrane/granule sensor for nucleic acids based on ion flux, circulating tumor cell and vesicle separation devices, biomolecule concentration and stacking by electrokinetic depletion/isotachophoresis, nanopore cell lysing and transfection, high-resolution microRNA profiling array based on tip plasmonics, single cell isolation by surface acoustic waves, free-flow isoelectric separation of proteins by on-chip pH actuation and patterning, photoconductive/nanowire transistor sensors. The emphasis is on low-cost and portable devices that can be used by lay people, without significant loss in sensitivity and selectivity.