Professor, Department of Chemical and Biomolecular Engineering
University of Notre Dame
Developing biomolecules and nanoparticles that target chemotherapeutic drugs
Using his expertise in bioengineering, biophysical chemistry, synthetic chemistry, and targeted drug delivery, he has been focusing his efforts on better understanding the principles of multivalent biomolecular interactions — the interactions of the multiple ligands present on molecules of all kinds — in an effort to redesign drugs used in chemotherapy for enhanced selectivity.
His group is developing biomolecules and nanoparticles to carry chemotherapeutic drugs, that are released selectively when the particles attach to the cancerous cells they have been designed to seek and find. Currently, his group is putting their efforts in designing such therapeutics for multiple myeloma and breast cancer.