Midwest Tumor Microenvironment Conference 2019 - Full Schedule
Speakers for Midwest Tumor Microenvironment Meeting
MONDAY, MAY 20
1:00-2:00 PM Check-in & Poster Setup Jordan Hall of Science, Galleria
2:00-3:00 PM NETWORKING POWER HOUR Jordan Hall of Science, Galleria
3:00-3:20 PM WELCOME AND INTRODUCTION Jordan Hall of Science, Auditorium Rm. 101
Laurie Littlepage, University of Notre Dame
Robert Bernhard, Vice President of Research, University of Notre Dame
SESSION 1. ACTIVATING AN ANTI-TUMOR IMMUNE RESPONSE
Session Chairperson: Xin Lu University of Notre Dame
3:20-3:35 PM Michael Dwinell Professor, Medical College of Wisconsin
Innate immune activation of anti-tumor T cell responses in pancreatic cancer
3:35-3:50 PM Christopher Halbrook Postdoctoral Fellow, University of Michigan (Labs of Costas Lyssiotis and Marina Pasca di Magliano)
Macrophage-Epithelial Metabolic Crosstalk Impairs Chemotherapy in Pancreatic Cancer
3:50-4:05 PM Sharif Rahmy Graduate student, University of Notre Dame (Xin Lu’s lab)
Identifying functional drivers of immunotherapy resistance
4:05-4:20 PM BREAK Jordan Hall of Science, Galleria
SESSION 2. GETTING TO THE METASTATIC SITE: TRANSPORT VIA LYMPHATIC AND VASCULATURE SYSTEMS
Session Chairperson: Donny Hanjaya-Putra Assistant Professor, University of Notre Dame
4:20-4:35 PM Laura Alderfer Graduate Student, University of Notre Dame (Donny Hanjaya-Putra’s lab)
Lymphangiogenesis Model to Study the Interplay between Mechanical and Biochemical Cues in the Metastatic Breast Cancer Microenvironment
4:35-4:50 PM Devon Moose Graduate Student, University of Iowa (Michael Henry’s lab)
Cancer Cells Adapt to Hemodynamic Forces to Survive Transit in Circulation and Enhance Metastatic Behavior
4:50-5:05 PM Gregory Timp Professor, University of Notre Dame
Cancer Cell Intra-/Extravasation Dynamics in an In Vitro Model of Human Microcirculation
5:05-5:20 PM Maria Virumbrales-Munoz University of Wisconsin (David Beebe’s lab)
Lumen-based microfluidic model of renal cell carcinoma microenvironment for antiangiogenic precision oncology
5:20-5:35 PM Bashar Emon Graduate Student, University of Illinois, Urbana-Champaign (Taher Saif’s lab)
Ultra-resolution sensor for quantification of single/multi-cellular traction dynamics in three dimensional biopolymers
5:35-5:50 PM Sharon Stack, Director, Harper Cancer Research Institute; Professor, University of Notre Dame
Intraperitoneal Mechanobiology and Ovarian Cancer Metastatic Success
5:50-6:00 PM BREAK
6:00-6:30 PM POSTER BLITZ 1 Jordan Hall of Science, Auditorium Rm. 101
6:30-8:30 PM POSTER SESSION 1 & RECEPTION (heavy hor d’oeuvres provided)
Jordan Hall of Science, Galleria
TUESDAY, MAY 21
8:00-9:00 AM BREAKFAST & POSTER SETUP Jordan Hall of Science, Galleria
SESSION 3. CELLULAR STRESS AND REPROGRAMMING NUTRIENT SIGNALING
Session Chairperson: Lisa Arendt University of Wisconsin
9:00-9:15 AM Tyvette Hilliard Research Assistant Professor, University of Notre Dame
Exploring the Role of Maternal Dietary Influence on Ovarian Cancer Metastasis in Next Generation Offspring
9:15-9:30 AM Chen Dai Graduate Student, University of Notre Dame (Laurie Littlepage’s lab)
Aquaporin-7 Modulates Lipid, Carbohydrate, Glutathione, and Arginine Metabolism in Breast Cancer Progression
9:30-9:45 AM Lauren Hillers-Ziemer Graduate Student, University of Wisconsin (Lisa Arendt’s lab)
Obesity promotes cooperation of cancer stem-like cells and macrophages to enhance mammary tumor angiogenesis
9:45-10:00 AM Peter Kim Graduate Student, University of Michigan (Costas Lyssiotis’s lab)
Defining the Role of the Hexosamine Biosynthesis Pathway in Pancreatic Cancer
10:00-10:10 AM Katharine White Assistant Professor, University of Notre Dame
Spatiotemporal pH dynamics and heterogeneity in cancer
10:10-10:25 AM Jose Ayuso Postdoctoral Fellow, University of Wisconsin (Melissa Skala’s lab)
Microfluidic models to study tumor and immune metabolism in solid tumors
10:25-10:40 AM BREAK
SESSION 4. INFLAMMATION, FIBROSIS, AND CARCINOMA ASSOCIATED FIBROblasts
Session Chairperson: Shrikant Anant University of Kansas Medical Center
10:40-10:50 AM Pilar de la Puente Assistant Scientist, Sanford School of Medicine, University of South Dakota
Plasma-Derived 3D Engineered Tumor Microenvironment (3DeTME) Cultures Promote Breast Cancer (BC) Proliferation, Recreate Drug Resistance, Intra-tumoral Hypoxia, and Immune Evasion
10:50-11:00 AM Hossein Tavana Associate Professor, The University of Akron
Three-Dimensional Tumor Models to Investigate Tumor-Stromal Interactions and Drug Resistance
11:00-11:15 AM Rekha Rao Manepolli Assistant Professor, University of Kansas Medical Center
ROS and Egr-1 axis promote bone marrow fibrosis in primary myelofibrosis.
11:15-11:30 AM Omar Franco Research Scientist, NorthShore University HealthSystem, University of Illinois at Chicago
Activation of Neurotrophin signaling in prostate cancer health disparity
11:30-11:45 AM Dharmalingam Subramaniam Research Assistant Professor, University of Kansas Medical Center
Cancer Associated fibroblasts modulating activity of DCLK1 positive cells in Pancreatic Cancer
11:45 AM-12:00 PM POSTER BLITZ 2 Jordan Hall of Science, Auditorium Rm. 101
12:00-2:00 PM LUNCH AND POSTER SESSION 2 Jordan Hall of Science, Galleria
SESSION 5. METASTATIC NICHE
Session Chairperson: Siyuan Zhang Associate Professor, University of Notre Dame
2:00-2:15 PM Leah Cook Assistant Professor, University of Nebraska
Bone-resident neutrophils are mediators of prostate cancer growth in bone
2:15-2:30 PM Samira Azarin Assistant Professor, University of Minnesota
Utilizing stem cell-derived models of the blood-brain barrier to study mechanisms of breast cancer metastasis to the brain
2:30-2:45 PM Ian Guldner Graduate Student, University of Notre Dame (Siyuan Zhang’s lab)
Microglia subset revealed by single cell analyses promotes brain metastasis outgrowth through fractalkine receptor-dependent interferon response
2:45-3:00 PM Anirban Mitra Assistant Professor, Indiana University School of Medicine – Bloomington
Deregulation of microRNAs and transcription factors by paracrine signals from the microenvironment drives ovarian cancer metastatic colonization
3:00-3:15 PM BREAK Jordan Hall of Science, Galleria
SESSION 6. EXTRACELLULAR MATRIX & ECM SIGNALING
Session Chairperson: Suzanne Ponik Senior Scientist, University of Wisconsin
3:15-3:30 PM András Czirók Associate Professor, University of Kansas Medical School
ECM scaffolds to elucidate the role of Col11a1 in head and neck cancer progression
3:30-3:45 PM Zachary Schafer Associate Professor, University of Notre Dame
The Regulation of Cancer Cell Death by Extracellular Matrix Attachment
3:45-4:00 PM Luis Solorio Assistant Professor, Purdue University
The Role of Active Fibronectin Signaling in Breast Cancer Metastasis
4:00-4:15 PM BREAK Jordan Hall of Science, Galleria
SESSION 7. TARGETS, RESPONSE TO THERAPY, AND THERAPEUTICS
Session Chairperson: Jenifer Prosperi Assistant Professor, Indiana University School of Medicine-South Bend
4:15-4:30 PM Zhangting Yao Postdoctoral Fellow, Washington University (Sheila Stewart’s lab)
Targeting Senescence in Chemotherapy-induced Bone Loss
4:30-4:45 PM Başar Bilgiçer Associate Professor, University of Notre Dame
Optimizing Nanoparticle Design Parameters for Enhanced Particle Delivery in an in vivo Multiple Myeloma Disease Model
4:45-5:00 PM Robert Kazmierczak Postdoctoral Fellow, University of Missouri (C. Yves Chuba lab)
Developing a Bacterial Cancer Targeting Biologic
5:00-5:15 PM David Standing Graduate Student, University of Kansas Medical Center (Shrikant Anant’s lab)
Elucidating the role of IRAK1 in OvCa chemoresistance and progression
6:05-6:15 PM Niranjan Awasthi Senior Research Professor, Indiana University School of Medicine, South Bend
Stroma-directed effects of anti-MMP9 antibody augment nab-paclitaxel/gemcitabine chemotherapy response in preclinical models of pancreatic cancer
WEDNESDAY, MAY 22
8:00-9:00 AM BREAKFAST & POSTER SETUP Jordan Hall of Science, Galleria
SESSION 8. REPROGRAMMING THE MICROENVIRONMENT: IMMUNE MODULATION AND MICROENVIRONMENT CROSSTALK 1
Session Chairperson: Sheila Stewart Washington University
9:00-9:15 AM Nikki Cheng Associate Professor, University of Kansas Medical School
Role of the immune and angiogenic microenvironment in CCR2 chemokine receptor mediated breast tumor growth and invasion
9:15-9:30 AM Ashley Velez-Delgado University of Michigan (Marina Pasca di Magliano’s lab)
Oncogenic Kras modulates the immune infiltration and function during pancreatic carcinogenesis
9:30-9:45 AM Austin Boucher Graduate Student, Indiana University School of Medicine-South Bend and University of Notre Dame (Richard Dahl’s lab)
The role of microRNA cluster mirn23a in macrophage polarization
9:45-10:00 AM Genevra Kuziel Graduate Student, University of Wisconsin (Lisa Arendt’s lab)
Inflammation-induced CD11b+ cells contribute to mammary tumor fibrosis
10:00-10:15 AM BREAK Jordan Hall of Science, Galleria
SESSION 9. REPROGRAMMING THE MICROENVIRONMENT: IMMUNE MODULATION AND MICROENVIRONMENT CROSSTALK 2
Session Chairperson: Michael Wendt Assistant Professor, Purdue University
10:15-10:30 AM Ammara Abdullah Postdoctoral Fellow, Purdue (Michael Wendt’s lab)
Neuropilin 1 is required for fibroblast growth factor receptor-mediated tumor progression
10:30-10:45 AM Paul Macklin Associate Professor, Indiana University
HPC-accelerated exploration and design of cell-based therapeutics
10:45-11:00 AM Rosa Menjivar Graduate Student, University of Michigan (Marina Pasca di Magliano’s lab)
Investigating the Effect of Myeloid Arg1 Ablation on Tumor Growth and CD8+ T Cell Infiltration and Activation in Pancreatic Cancer
11:00-11:15 AM Songhai Chen Associate Professor, University of Iowa
Transactivation of HER2 by GPCR signaling promotes HER2+ breast cancer progression and therapeutic resistance
SESSION 10. Reprogramming the Microenvironment: Immune Modulation and Microenvironment Crosstalk 3
Session Chairperson: Richard Dahl Associate Professor, Indiana University School of Medicine-South Bend
11:15-11:25 AM Olivia Provance Graduate Student, University of Kansas Medical School (Joan Lewis-Wambi’s lab)
Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
11:25-11:35 AM Zeinab Ramshani Postdoctoral Fellow, University of Notre Dame (Hsueh-Chia Chang and David Go’s labs)
An Integrated Microfluidic Platform for Quantifying microRNA Cancer Biomarkers
11:35-11:45 AM Ryan Carr Postdoctoral Fellow, Mayo Clinic (Martin E. Fernandez-Zapico’s lab)
A novel GLI1-STAT3 transcriptional complex acts as effector of the extracellular sulfatase, SULF2, to promote liver tumorigenesis
11:45-11:55 AM Christina Mark Graduate Student, University of Wisconsin (Shigeki Miyamoto’s lab)
Non-genetic, tumor microenvironment-based mechanisms of multiple myeloma drug resistance
11:55 AM CLOSING
12:00 PM LUNCH (BOXED TO GO)