Our group is focused on the development of chemical and biological synthetic technologies for the production of natural products and natural product analogues and the study of their therapeutic potential for cancer and rare disease indications. In our lab, chemical synthesis tools such as methodology development and total synthesis are complemented by biological synthesis techniques such as bacterial fermentation, genetic and chemical manipulation, and heterologous expression. The power of synthesis enables access to the complex structures that are the foundation for a medicinal chemistry program. Recent efforts have identified compounds have identified compounds which modulate alternative mRNA splicing and have therapeutic potential for certain forms of acute myeloid leukemia and neurodegenerative diseases.