Professor, Biological Sciences
University of Notre Dame
Email: Crislyn D'Souza-Shorey
Office: 145 Galvin Life Sciences
New insights into tumor progression: biology and clinical promise
Crislyn D’Souza-Schorey joined the Notre Dame faculty as the Walther Cancer Institute Junior Chair. Over the past decade, her laboratory in biological sciences has investigated cellular changes that lead to metastasis, the major life-threatening clinical manifestation of cancer. The acquisition of the invasive phenotype — when cells acquire the ability to break away from the primary tumor and invade through the surrounding tissue — is a critical step in metastasis, and has been the focal point of the laboratory’s research. This development drastically reduces the patient’s chance of survival.
Using cell and animal model systems, the laboratory has identified key regulators of epithelial glandular disruption characteristic of early breast tumor development as well as mechanisms that remodel the tumor microenvironment, characteristic of advanced disease. With a focus on breast and ovarian cancer, current efforts involve an interdisciplinary collaboration between cell biologists, biochemists, physicians, and bioengineers to develop a program that builds on recent findings and will aid in discovery of cancer biomarkers and new drug targets.